Center for In-Vivo

Hyperpolarized Gas MR Imaging

Abstracts from U.Va on Hyperpolarized Noble Gas MR:

Publications from U.Va on Hyperpolarized Noble Gas MR:

Cai J, Miller GW, Altes TA, Read PW, Benedict SH, de Lange EE, Cates GD, Brookeman JR, Mugler III JP, Sheng K. Direct Measurement of Lung Motion Using Hyperpolarized Helium-3 MR Tagging. International Journal of Radiation Oncology*Biology*Physics 2007/7/1; 68:650-653.

de Lange EE, Altes TA, Patrie JT, Parmar J, Brookeman JR, Mugler III JP, Platts-Mills TAE. The variability of regional airflow obstruction within the lungs of patients with asthma: Assessment with hyperpolarized helium-3 magnetic resonance imaging. Journal of Allergy and Clinical Immunology 2007/5; 119:1072-1078.

Mata JF, Altes TA, Cai J, Ruppert K, Mitzner W, Hagspiel KD, Patel B, Salerno M, Brookeman JR, de Lange EE, Tobias WA, Wang HTJ, Cates GD, Mugler III JP. Evaluation of emphysema severity and progression in a rabbit model: comparison of hyperpolarized 3He and 129Xe diffusion MRI with lung morphometry. J Appl Physiol 2007; 102:1273-1280.

O'Halloran RL, Holmes JH, Altes TA, Salerno M, Fain SB. The effects of SNR on ADC measurements in diffusion-weighted hyperpolarized He-3 MRI. Journal of Magnetic Resonance 2007/3; 185:42-49.

Altes TA, Mata JF, de Lange EE, Brookeman JR, Mugler III JP. Assessment of lung development using hyperpolarized helium-3 diffusion MR imaging. Journal of Magnetic Resonance Imaging 2006; 24:1277-1283.

de Lange EE. Science to Practice: What Is New about Detecting Emphysema? Radiology 2006; 239:619-620.

de Lange EE, Altes TA, Patrie JT, Gaare JD, Knake JJ, Mugler III JP, Platts-MillsTA. Evaluation of Asthma With Hyperpolarized Helium-3 MRI: Correlation With Clinical Severity and Spirometry. Chest 2006; 130:1055-1062.

Shanbhag DD, Altes TA, Miller GW, Mata JF, Knight-Scott J. q-space analysis of lung morphometry in vivo with hyperpolarized 3He spectroscopy. Journal of Magnetic Resonance Imaging 2006; 24:84-94.

Wang CG, Miller GW, Altes TA, de Lange EE, Cates GD Jr., Mugler III JP. Time dependence of 3He diffusion in the human lung: Measurement in the long-time regime using stimulated echoes. Magnetic Resonance in Medicine 2006; 56:296-309.

Altes TA, Mai VM, Munger TM, Brookeman JR, Hagspiel KD. Pulmonary Embolism: Comprehensive Evaluation with MR Ventilation and Perfusion Scanning with Hyperpolarized Helium-3, Arterial Spin Tagging, and Contrast-enhanced MRA. J Vasc Interv Radiol 2005; 16:999-1005.

Mentore K, Froh DK, de Lange EE, Brookeman JR, Paget-Brown AO, Altes TA. Hyperpolarized HHe 3 MRI of the Lung in Cystic Fibrosis: Assessment at Baseline and After Bronchodilator and Airway Clearance Treatment. Academic Radiology 2005/11; 12:1423-1429.

Salerno M, Brookeman JR, de Lange EE, Mugler III JP. Hyperpolarized 3He lung imaging at 0.5 and 1.5 Tesla: A study of susceptibility-induced effects. Magnetic Resonance in Medicine 2005; 53:212-216.

Altes TA, Salerno M. Hyperpolarized Gas MR Imaging of the Lung. Journal of Thoracic Imaging 2004; 19:250-258.

Altes TA, Rehm PK, Harrell F, Salerno M, Daniel TM, de Lange EE. Ventilation imaging of the lung: Comparison of hyperpolarized helium-3 MR imaging with Xe-129 scintigraphy. Academic Radiology 2004/7; 11:729-734.

Miller GW, Altes TA, Brookeman JR, De Lange EE, Mugler JP. Hyperpolarized 3He lung ventilation imaging with B1-inhomogeneity correction in a single breath-hold scan. Magnetic Resonance Materials in Physics, Biology and Medicine 2004; 16:218-226.

Altes TA, de Lange EE. Applications of Hyperpolarized Helium-3 Gas Magnetic Resonance Imaging in Pediatric Lung Disease. Topics in Magnetic Resonance Imaging 2003; 14:231-236.

Ray N, Acton ST, Altes T, de Lange EE, Brookeman JR. Merging parametric active contours within homogeneous image regions for MRI-based lung segmentation. IEEE Transactions on Medical Imaging 2003; 22:189-199.

Salerno M, Altes TA, Brookeman JR, de Lange EE, Mugler III. JP. Rapid hyperpolarized 3He diffusion MRI of healthy and emphysematous human lungs using an optimized interleaved-spiral pulse sequence. Journal of Magnetic Resonance Imaging 2003; 17:581-588.

Samee S, Altes TA, Powers P, de Lange EE, Knight-Scott J, Rakes G, Mugler III JP, Ciambotti JM, Alford BA, Brookeman JR, Platts-Mills TAE. Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: Assessment of response to methacholine and exercise challenge. Journal of Allergy and Clinical Immunology 2003/6; 111:1205-1211.

Salerno M, de Lange EE, Altes TA, Truwit JD, Brookeman JR, Mugler III JP.Hyperpolarized 3He diffusion MRI of the lungs in emphysema: Comparison with pulmonary function tests --Initial experience. Radiology 2002; 222:252-260.Salerno M, Altes TA, Brookeman JR, de Lange EE, Mugler III JP.

Dynamic spiral MR imaging of pulmonary gas flow using hyperpolarized 3He: Preliminary studies in healthy and diseased lungs. Magn Reson Med 2001; (in press)

Salerno M, Altes TA, Mugler III JP, Nakatsu M, Hatabu H, de Lange EE.
Hyperpolarized noble gas MR imaging of the lung: Emerging clinical applications.
Eur J Radiol 2001; (in press).

Altes TA, Powers PL, Knight-Scott J, Rakes G, Platts-Mills TAE, de Lange EE, Alford BA, Mugler III JP, Brookeman JR. Hyperpolarized 3He MR Lung Ventilation Imaging in Asthmatics: Preliminary Findings.
Accepted for publication in JMRI and as one of 3 finalists for the WS Moore Young Investigators award in Clinical Science, ISMRM 8th Annual Meeting, Denver CO, April 2000.J Magn Reson Imaging 2001; 13:378-384.

Hagspiel KD, Altes TA, Mugler III JP, Spellman MJ, Mata JF, Tustison NJ, Brookeman JR. MR Virtual Colonography Using Hyperpolarized 3He as an Endoluminal Contrast Agent. Demonstration of feas0ibility.Magn Reson Med 2000; 44:813-816.

Hagspiel K, Altes T, Mugler III JP,  Brookeman J.
Magnetic Ressonance Hysterography and  Hysterosalpingography Using Hyperpolarized Helium-3: Demonstration of feasability in an animal model.
J Magn Reson Imaging 2000; 12:1009-1013.

Ruppert K, Brookeman JR, Hagspiel KD, Mugler III JP.
Probing Lung Physiology with Xenon Polarization Transfer Contrast (XTC).
Accepted for publication in MRM and as one of 3 finalists for the II Rabi Young Investigators award in Basic Science, ISMRM 8th Annual Meeting, Denver CO, April 2000.  Magn Reson Med 2000;44:349-357.

Ruppert K, Brookeman J, Hagspiel K, Driehuys B, Mugler J.
NMR of Hyperpolarized Xe-129 in the Canine Chest: Spectral Dynamics during a Breath-hold. NMR Biomed 2000; 13:220-228.

Stith A, Hitchens T, Hinton D, Berr S, Driehuys B, Brookeman J, Bryant R.
Consequences of 129 Xe - 1 H Cross Relaxation in Aqueous Solutions.
Journal of Magnetic Resonance, 139:225-231, 1999.
Local Abstract

Teates CD, Brookeman JR, Daniel TM, Truwit JD, Parekh JS, Mugler III JP, de Lang EE. The Stripe Sign: Correlation of Radionuclide Ventilation and Perfusion with He-3 Magnetic Resonance Lung Imaging. Clinical Nuclear Medicine, 24:747-750, 1999.

de Lange EE, Mugler JP, Brookeman JR, Knight-Scott J, Truwit J, Teates CD, Daniel TM, Bogorad PL, Cates GD. Lung Airspaces: MR Imaging Evaluation with Hyperpolarized Helium-3 Gas.
Radiology 1999; 210:851-857.

Mugler III JP, Bogorad P, Driehuys B, Brookeman J. Nuclear Magnetic Resonance Using Hyperpolarized Noble Gases.
A review paper to be published in the Journal of Magnetic Resonance Analysis.

Mugler III JP, Driehuys B, Hagspiel K, Ruppert K, Cates G, Altes T, Spellman M, Munger T, Mata J, Brookeman J. Dissolved-Phase Xe-129 Spectroscopy: Impact of Polarization Improvements.
(submitted to Journal European Radiology, June 1999 ).

Brookeman J, Mugler III JP, Knight-Scott J, Munger T, De Lange E, Bogorad P.
Studies of He-3 Diffusion coefficient in the Human Lung: Age-Related Distribution Patterns.
(Submitted to Journal European Radiology, June 1999).

Hagspiel K, Mugler III JP, Altes T, De Lange E, Knight-Scott J, Munger T, Berr S, Mai V, Daniel T, Spellman M, Mata J, Bogorad P, Driehuys B, Gentile T, Jones G, Thompson A, Brookeman J. Static MR Imaging of the Airways Using Hyperpolarized He-3 and Xe-129: The University of Virginia Experience.
(Submitted to Journal European Radiology, June 1999).

Gentile T, Jones G, Thompson A, Rizi R, Lipson D, Roberts D, Schnall M, Brookeman J, Mugler III JP.
A Compact Compressor for Application of Metastability-Exchange Optical Pumping of He-3 to Human Imaging.
(Submitted to Journal European Radiology, June 1999).

Brookeman JR.
MRS and MRI of Hyperpolarized 129XE: Studies in Human Volunteers.
Syllabus for Advanced Magnetic Resonance Spectroscopy Course.
Sixth Scientific Meeting Society of Magnetic Resonance in Medicine,
Sydney, Australia, April 1998.

Brookeman JR, Mugler III JP, Bogorad P, Daniel TM, de Lange EE, Driehuys B, Knight-Scott J, Maier T, Truwit JD, Cates G, Happer W.
Polarized Noble Gas MRI
In "Polarized Gas Targets and Polarized Beams",
edited by Roy J. Holt, Pub Am Inst of Physics 213 - 217, 1998.

Mugler JP, Driehuys B, Brookeman JR, Cates GD, Berr SS, et al.
MR Imaging and Spectroscopy Using Hyperpolarized Xe-129 Gas: Preliminary Human Results. MRM 1997; 38: 809 - 812.

Last Modified: June 27, 2007